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인천재능대학교 송도바이오과 교수소개 입니다.
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리스트
이 름 이경화 직 위 부교수
주전공 생화학
담당과목 분자생물학, 바이오기기분석,창의프로젝트
전화번호 032-890-7516 연구실 송도캠퍼스 2층-2
e-mail lee12042@jeiu.ac.kr
연세대학교 생화학과 이학박사
  • 연세대학교 생화학과 졸업
  • 연세대학교 생화학과 석사
  • 연세대학교 생화학과 박사
  • 미국 국립 보건원 (NIH) Visiting Fellow
  • 서울대병원 의생명연구원 연구교수
  • PUBLICATIONS
  • Lee KH, Kim BC, Jeong CW, Ku JH, Kim HH, Kwak C. MLL5, a histone modifying enzyme, regulates androgen receptor activity in prostate cancer cells by recruiting co-regulators, HCF1 and SET1. BMB Rep. 2020 Dec;53(12):634-639. doi: 10.5483/BMBRep.2020.53.12.162.
  • Lee KH, Kim BC, Jeong SH, Jeong CW, Ku JH, Kwak C, Kim HH. Histone Demethylase LSD1 Regulates Kidney Cancer Progression by Modulating Androgen Receptor Activity. Int J Mol Sci. 2020 Aug 24;21(17):E6089. doi: 10.3390/ijms21176089.
  • Lee KH, Kim BC, Jeong SH, Jeong CW, Ku JH, Kim HH, Kwak C. Histone Demethylase KDM7A Regulates Androgen Receptor Activity, and Its Chemical Inhibitor TC-E 5002 Overcomes Cisplatin-Resistance in Bladder Cancer Cells. Int J Mol Sci. 2020 Aug 6;21(16):E5658. doi: 10.3390/ijms21165658.
  • Kim S, Kim Y, Kong J, Kim E, Choi JH, Yuk HD, Lee H, Kim HR, Lee KH, Kang M, Roe JS, Moon KC, Kim S, Ku JH, Shin K. Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer. Elife. 2019 Apr 30;8:e43024. doi: 10.7554/eLife.43024.
  • Lee KH, Hong S, Kang M, Jeong CW, Ku JH, Kim HH, Kwak C. Histone demethylase KDM7A controls androgen receptor activity and tumor growth in prostate cancer. Int J Cancer. 2018 Dec 1;143(11):2849-2861. doi: 10.1002/ijc.31843. Epub 2018 Oct 9.
  • Lee KH, Ku JH. Targeting splicing factors as molecular non-muscle invasive bladder cancer predictors. Transl Androl Urol. 2018 Dec;7(Suppl 6): S715-S717. doi: 10.21037/tau.2018.10.09.
  • Lee KH, Song CG. Epigenetic regulation in bladder cancer: development of new prognostic targets and therapeutic implications. Transl Cancer Res 2017; 6 (Suppl 4):S677-S688
  • Kang M, Lee KH, Lee HS, Jeong CW, Ku JH, Kim HH, Kwak C. Concurrent treatment with simvastatin and NF-κB inhibitor in human castration-resistant prostate cancer cells exerts synergistic anti-cancer effects via control of the NF-κB/LIN28/let-7 miRNA signaling pathway. PLoS One. 2017 Sep 14;12(9):e0184644. doi: 10.1371/journal.pone.0184644. eCollection 2017.
  • Lee JH, Jeon YG, Lee KH, Lee HW, Park J, Jang H, Kang M, Lee HS, Cho HJ, Nam DH, Kwak C, Kim JB. RNF20 Suppresses Tumorigenesis by Inhibiting SREBP1c-PTTG1 Axis in Kidney Cancer. Mol Cell Biol. 2017 Aug 21.doi: 10.1128/MCB.00265-17
  • Kang M, Lee KH, Lee HS, Jeong CW, Kwak C, Kim HH, Ku JH. Concurrent Autophagy Inhibition Overcomes the Resistance of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Human Bladder Cancer Cells. Int J Mol Sci. 2017 Feb 4;18(2). pii: E321. doi: 10.3390 ijms18020321.
  • Kang M, Lee KH, Lee HS, Park YH, Jeong CW, Ku JH, Kim HH, Kwak C. PDLIM2 suppression efficiently reduces tumor growth and invasiveness of human castration-resistant prostate cancer-like cells. Prostate. 2016 Feb 15. 76(3):273-85. doi: 10.1002/pros.23118.
  • Lee KH, Park JW, Sung HS, Choi YJ, Kim WH, Lee HS, Chung HJ, Shin HW, Cho CH, Kim TY, Li SH, Youn HD, Kim SJ, Chun YS. PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer. Oncogene. 2015 May 28;34(22):2897-909
  • Yoon HJ, Kim HL, Chun YS, Shin DH, Lee KH, Shin CS, Lee DY, Kim HH, Lee ZH, Ryoo HM, Lee MN, Oh GT, Park JW. NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2. Nature Communications. 2014 Nov; 5:5176
  • Lee KH, Ju UI, Song JY, Chun YS. The histone demethylase PHF2 promotes fat cell differentiation as an epigenetic activator of both C/EBPα and C/EBPδ. Molecules and Cells. 2014 Oct; 37(10):734-741. Co-corresponding author
  • Kim HJ, Park JW, Lee KH, Yoon H, Shin DH, Ju UI, Seok SH, LimSH, Lee ZH, Kim HH, Chun YS. Plant homeodomain finger protein 2 promotes bone formation by demethylating and activating Runx2 for osteoblast differentiation. Cell Research. 2014 Oct; 24(10):1231-49.
  • Shin HW, Choi H, So D, Kim YI, Cho K, Chung HJ, Lee KH, Chun YS, Cho CH, Kang GH, Kim WH, Park JW. ITF2 Prevents Activation of the βcatenin-TCF4 Complex in Colon Cancer Cells and Levels Decrease with Tumor Progression. Gastroenterology. 2014 Aug; 147(2):430-442.
  • Zhang X, He Y, Lee KH, Dubois W, Li Z, Wu X, Kovalchuk A, Zhang W, Huang J. Rap2b, a novel p53 target, regulates p53-mediated pro-survival function. Cell Cycle. 2013 Apr; 12(8):1279-1291.
  • Kim MK, Yang S, Lee KH, Um JH, Liu M, Kang H, Park SJ, Chung JH. 301. Am J Physiol Endocrinol Metab. 2011 Dec; 301(6):E1130-42. Equally contributed
  • Lee KH. CaMKII inhibitor KN-62 blunts tumor response to hypoxia by inhibiting HIF-1 in hepatoma cells. Kor J Physiol Pharmacol. 2010 Oct: 14(5):331-336.
  • Lee KH, Li MM, Michalowski A, Zang X, Liao H, Chen L, Xu Y, Wu X and Huang J. A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine
  • embryonic stem cells. Proc Natl Acad Sci U S A., 2010 Jan 5; 107(1):69-74
  • Lee KH, Choi EJ, Chun YS, Kim MS and Park JW. Differential responses of two degradation domains of HIF- 1α to hypoxia and iron deficiency. Biochemi. 2006 Feb; 88(2):163-169.
  • Kim DH, Lee KH, Kim JH, Ryu GH, Bae SH, Lee BC, Moon KY, Byun SM, Koo HS and Seo YS. Enzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2. Nucleic Acids Res. 2005 Mar 3; 33(4):1372-1383.
  • Lee KH, Park JW, Chun YS. Non-hypoxic Transcriptional Activation of the Aryl Hydrocarbon Receptor Nuclear Translocator in Concert with a Novel Hypoxia-Inducible Factor-1alpha Isoform. Nucleic Acids Res. 2004 Oct 12;32(18):5499-511.
  • Chun YS, Lee KH, Choi E, Bae SY, Yeo EJ, Huang LE, Kim MS, Park JW. Phorbol Ester Stimulates the Nonhypoxic Induction of a Novel Hypoxia-Inducible Factor 1alpha Isoform: Implications for Tumor Promotion. Cancer Res. 2003 Dec 15;63(24):8700-8707. Equally contributed.
  • Lee KH, Lee MH, Lee TH, Han JW, Park YJ, Ahnn JH and Hyeon-Sook Koo. Dna2 Requirement for Normal Reproduction of Caenorhabditis elegans is Temperature-Dependent. Mol. Cells, 2003, 15, 81-86.
  • Bae SH, Kim JA, Choi E, Lee KH, Kang HY, Kim HD, Kim JH, Bae KH, Cho Y, Park C, Seo YS. Tripartite Structure of Saccharomyces cerevisiae Dna2 Helicase/Endonuclease. Nucleic Acids Res. 2001, 29,3069-79.
  • Lee KH, Kim DW, Bae SH, Kim JA, Ryu GH, Kwon YN, Kim KA, Koo HS, Seo YS. The Endonuclease Activity of the Yeast Dna2 Enzyme is Essential in vivo. Nucleic Acids Res. 2000, 28, 2873-81.
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